Location – R. Eliezer wandered widely throughout his life,2 spending time in Egypt, Cyprus, Italy, Crimea, Cracow, and Prague.
Occupation – R. Eliezer served in many different rabbinic positions,3 notably for 22 years in Egypt. His many travels gave him extensive knowledge of the politics, culture, and realia of different societies, knowledge which impacted his commentaries.4
Family – R. Eliezer's father was R. Eliyah HaRofe, and his mother was the daughter of R. Yosef Colon (Maharik). He and his wife Rachel had two sons5 and a daughter.
Teachers – R. Eliezer studied Talmud under R. Yosef Taitazak in Salonica.
Contemporaries – R. Meir Padua, R. Shemuel Yehudah Katzenellenbogen,6 R. David Ibn Zimra (Radbaz), R. Betzalel Ashkenazi,7 R. Yosef Karo,8 R. Moshe Isserles, Maharal.
Time period – R. Eliezer was raised in Renaissance Italy, which may have impacted on his thought.9